Abstract:

BACKGROUND: Few reports about the stability of nanoparticles in the water and PBS have been published in China.
OBJECTIVE: To investigate the stability of pluronic/poly(lactic acid) nanoparcticles in the water and PBS and feasibility of pluronic F127/poly(lactic acid) block polymer as drug carriers
METHODS: Pluronic poly(lactic acid) nanoparcticles were prepared by a dialysis method. In vitro high performance liquid chromatography, and the cytotoxicity of pluronic F127/poly(lactic acid) block polymer was investigated by MTT.
RESULTS AND CONCLUSION: Pluronic /poly(lactic acid) nanoparticles had better stability in the water than in the PBS. In addition, pluronic /poly(lactic acid) nanoparticles were influenced greatly by the temperature, which had a good stability in low temperature. At 37 ℃, pluronic/poly(lactic acid) nanoparticles had a greater change in the particle size. The release curve of paclitaxel-loaded pluronic F127/poly(lactic acid) nanoparticles showed a rapid release within 20 hours, and then presented with a slow release. Approximately 20% paclitaxel was released from the nanoparticles. MTT test results revealed that pluronic F127/poly(lactic acid) block polymer had a good biocompatibility. These findings indicate that pluronic/poly(lactic acid) nanoparticles can be used as drug carriers.